AG Experimentelle Radiologie / Forschungslabor

AG Experimentelle Radiologie, Leiter: 
Prof. Dr. med. Dipl.-Phys. Matthias Taupitz 

Laborleiter 
Dr. med. vet. Jörg Schnorr 

Wissenschaftliche Mitarbeiter: 
Dr. rer. medic. Bettina Kelsch 
Dr. med. vet. Nicola Stolzenburg 
Dr. med. vet. Beatrix Schnorr 
Dr. med. vet. Ines Gemeinhardt 
Dr. rer. nat. Harald Kratz 
Dr. rer. nat. Ralf Hauptmann
Dr. rer. nat. Tobias Haase
Dr. rer. nat. Stefanie Kamann
PD Dr. Christian Freise
Dr. med. vet. Ole Gemeinhardt
Monika Ebert, CTA
Susanne Metzkow, CTA
Annette Kögel, Forschungssekretariat / Studienassistenz
Claudia Kuhn / Monitorin
Deanna Neubauer / Monitorin
Nina Chan-Wehe, Study Nurse / Monitorin 

Doktoranden:
Yavuz Oguz Uca
Azadeh Mohtashamdolatshahi
Franziska Rausch
Julia Kamischke
Maryam Azarian

Kooperation 

• Klinische Forschergruppe 

• InnoRa GmbH 

• MAPIT + Kooperationspartner: 
    Bayer Schering Pharma 
    Bruker-BioSpin 
    Philips Medical Systems 
    PTB Berlin 
    Universität zu Lübeck 

Alumni: 
Dr. med. vet. Claudia Abramjuk 
Corinna Meier-Windhorst 
Romina Turco 
Yuske Kobayashi 
Lena Figge 
Dr. rer. medic. Carsten. Warmuth 
Gesche Genter 
Thi-My Hanh Nguyen 
Janna Gläser 
Contantin Scharlach 
Franziska Appler 
Dr. med. vet. Susanne Wagner
Dr. rer. nat. Angela Ariza de Schellenberger

AG Molekulare Bildgebung, Leiter: 
Prof. Dr. med. Eyk Schellenberger 

Wissenschaftliche Mitarbeiter: 
Dr. rer. nat. Akvile Häckel 

Doktoranden: 

Fei Ni, Master's Degree in Medicine
Jing Xie, Master's Degree in Medicine
Lena Ascher, Biochemie
Alejandro Betancourt, Medizin

In freier Mitarbeit / Kooperation: 

AG Leiter: 
Prof. Dr. rer. nat. Ulrich Speck 

Wissenschaftliche Mitarbeiter: 
Dr. rer. nat. Thomas Speck 
Dr. med. vet. Melanie Löchel 
Dr. rer. nat. Stephanie Bienek 
Dr. rer. nat. Daniel Peters-Berg 
Dr. rer. nat. Denise Schütt 
Maciej Kusmierczuk, Ingenieur 
Dr. rer. nat. Melanie Herse-Näther
Dr. rer. nat. Stefanie Kamann
Dr. rer. nat. Maren Kutschera 

Doktoranden: 
Sebastian Schurmann-Kaufeld, Pharmakologe
Nadia Brunacci, Chemikerin

AG MR Elastographie, Leiter: 
Prof. Dr. rer. nat. Ingolf Sack 

In freier Mitarbeit / Kooperation: 
PD Dr. rer. nat. Jürgen Braun 

Wissenschaftliche Mitarbeiter: 
Dr. rer. nat. Jing Guo
Dr. rer nat. Heiko Tzschätzsch

Mediziner:
PD Dr. med. Patrick Asbach
PD Dr. med. Christian Althoff
PD Dr. med. Thomas Elgeti
Dr. med. Kaspar-Josche Streitberger
Dr. med. Rolf Reiter
Prof. Thom Fischer
Dr. med. Christian Hudert
Stephan Marticorena Garcia

PhD Student:
Gergely Bertalan
Felix Schrank
Ledia Lilaj
Bernhardt Kreft
Helge Herthum
Mehrgan Shahryari
Anna Morr
Karolina Garczynska
Jakob Jordan

Studenten: 


AG MR-Elastographie 

Resveratrol-Coated Balloon Catheters in Porcine Coronary and Peripheral Arteries
Kamann S, Haase T, Stolzenburg N, Löchel M, Peters D, Schnorr J.
Int J Mol Sci. 2019 May 9;20(9). pii: E2285. doi: 10.3390/ijms20092285.
PubMed

Two-Year Mortality After Angioplasty of the Femoro-Popliteal Artery with Uncoated Balloons and Paclitaxel-Coated Balloons-A Pooled Analysis of Four Randomized Controlled Multicenter Trials.
Albrecht T, Schnorr B, Kutschera M, Waliszewski MW.
Cardiovasc Intervent Radiol. 2019 Jul;42(7):949-955. doi: 10.1007/s00270-019-02194-w. Epub 2019 Mar 6.
PubMed

Treatment of Coronary Drug-Eluting Stent Restenosis by a Sirolimus- or Paclitaxel-Coated Balloon.
Ali RM, Abdul Kader MASK, Wan Ahmad WA, Ong TK, Liew HB, Omar AF, Mahmood Zuhdi AS, Nuruddin AA, Schnorr B, Scheller B.
JACC Cardiovasc Interv. 2019 Mar 25;12(6):558-566. doi: 10.1016/j.jcin.2018.11.040.
PubMed

Very small superparamagnetic iron oxide nanoparticles: Long-term fate and metabolic processing in atherosclerotic mice.
Poller WC, Pieber M, Boehm-Sturm P, Ramberger E, Karampelas V, Möller K, Schleicher M, Wiekhorst F, Löwa N, Wagner S, Schnorr J, Taupitz M, Stangl K, Stangl V, Ludwig A.
Nanomedicine. 2018 Sep 1;14(8):2575-2586. doi: 10.1016/j.nano.2018.07.013. [Epub ahead of print] PMID: 30179669

Renal Denervation by Transaortic Periarterial Ethanol Injection: An Experimental Study in Porcines.
Freyhardt P, Schütze J, Donners R, Schnorr J, Stolzenburg N, Rinnenthal JL, Penzkofer T, Hamm B, Günther RW, Streitparth F.
Cardiovasc Intervent Radiol. 2018 Aug 7. doi: 10.1007/s00270-018-2045-6. [Epub ahead of print] PMID: 30088063

Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies.
Kratz H, Taupitz M, Ariza de Schellenberger A, Kosch O, Eberbeck D, Wagner S, Trahms L, Hamm B, Schnorr J.
PLoS One. 2018 Jan 4;13(1):e0190214. doi: 10.1371/journal.pone.0190214. eCollection 2018. PMID: 29300729 

Drug Distribution and Basic Pharmacology of Paclitaxel/Resveratrol-Coated Balloon Catheters.
Speck U, Häckel A, Schellenberger E, Kamann S, Löchel M, Clever YP, Peters D, Scheller B, Trog S, Bettink S.
Cardiovasc Intervent Radiol. 2018 Oct;41(10):1599-1610. doi: 10.1007/s00270-018-2018-9. Epub 2018 Jul 2. PMID:29968090 

Low-Molecular-Weight Iron Chelates May Be an Alternative to Gadolinium-based Contrast Agents for T1-weighted Contrast-enhanced MR Imaging.
Boehm-Sturm P, Haeckel A, Hauptmann R, Mueller S, Kuhl CK, Schellenberger EA.
Radiology. 2018 Feb;286(2):537-546. doi: 10.1148/radiol.2017170116. Epub 2017 Sep 7. PMID:28880786

Two-Year Clinical Outcomes of the CONSEQUENT Trial: Can Femoropopliteal Lesions be Treated with Sustainable Clinical Results that are Economically Sound?
Albrecht T, Waliszewski M, Roca C, Redlich U, Tautenhahn J, Pech M, Halloul Z, Gögebakan Ö, Meyer DR, Gemeinhardt I, Zeller T, Müller-Hülsbeck S, Ott I, Tepe G. Cardiovasc Intervent Radiol. 2018 Jul;41(7):1008-1014. doi: 10.1007/s00270-018-1940-1. Epub 2018 Mar 27. PMID:29589098

Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography-A morphometric study of the mandibular canal.
Corte GM, Plendl J, Hünigen H, Richardson KC, Gemeinhardt O, Niehues SM.
PLoS One. 2017 Sep 14;12(9):e0184889. doi: 10.1371/journal.pone.0184889. eCollection 2017. PMID:28910382 

Finding Optimal Ablation Parameters for Multipolar Radiofrequency Ablation.
Poch FGM, Rieder C, Ballhausen H, Knappe V, Ritz JP, Gemeinhardt O, Kreis ME, Lehmann KS.Surg Innov.
2017 Jun;24(3):205-213. doi: 10.1177/1553350617692492. Epub 2017 Feb 13. PMID:28193132

Determination of the electrical conductivity of human liver metastases: impact on therapy planning in the radiofrequency ablation of liver tumors.
Zurbuchen U, Poch F, Gemeinhardt O, Kreis ME, Niehues SM, Vahldieck JL, Lehmann KS.
Acta Radiol. 2017 Feb;58(2):164-169. doi: 10.1177/0284185116639765. Epub 2016 Jul 20. PMID:27055920

Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis.
Figge L, Appler F, Chen HH, Sosnovik DE, Schnorr J, Seitz O, Taupitz M, Hamm B, Schellenberger E.
Contrast Media Mol Imaging. 2014 Jul-Aug;9(4):291-9. doi: 10.1002/cmmi.1575.

XTEN-annexin A5: XTEN allows complete expression of long-circulating protein-based imaging probes as recombinant alternative to PEGylation.
Haeckel A, Appler F, Figge L, Kratz H, Lukas M, Michel R, Schnorr J, Zille M, Hamm B, Schellenberger E.
J Nucl Med. 2014 Mar;55(3):508-14. doi: 10.2967/jnumed.113.128108. Epub 2014 Feb 18.

Synthetic routes to magnetic nanoparticles for MPI.
Kratz H, Eberbeck D, Wagner S, Taupitz M, Schnorr J.
Biomed Tech (Berl). 2013 Aug 15:1-7. doi: 10.1515/bmt-2012-0057. [Epub ahead of print]

Gadolinium-containing magnetic resonance contrast media: investigation on the possible transchelation of GdXXX to the glycosaminoglycan heparin.
Taupitz M, Stolzenburg N, Ebert M, Schnorr J, Hauptmann R, Kratz H, Hamm B, Wagner S.
Contrast Media Mol Imaging. 2013 Mar-Apr;8(2):108-16. doi: 10.1002/cmmi.1500.

Imaging of magnetic microfield distortions allows sensitive single-cell detection.
Lindquist RL, Papazoglou S, Scharlach C, Waiczies H, Schnorr J, Taupitz M, Hamm B, Schellenberger E.
Mol Imaging. 2013 Mar-Apr;12(2):83-9.

Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization.
Wagner S, Schnorr J, Ludwig A, Stangl V, Ebert M, Hamm B, Taupitz M.
Int J Nanomedicine. 2013;8:767-79. doi: 10.2147/IJN.S38702. Epub 2013 Feb 20.

Inhibition of neointimal proliferation after bare metal stent implantation with low-pressure drug delivery using a paclitaxel-coated balloon in porcine coronary arteries.
Cremers B, Kelsch B, Clever YP, Hattangadi N, Mahnkopf D, Speck U, Taupitz M, Scheller B.
Clin Res Cardiol. 2012 Jan 12. [Epub ahead of print]

Cardiac Magnetic Resonance Angiography using Blood-Pool Contrast Agents: Comparison of Citrate-Coated Very Small Superparamagnetic Iron Oxide Particles with Gadofosveset Trisodium in Pigs.
Schnorr J, Taupitz M, Schellenberger EA, Warmuth C, Fahlenkamp UL, Wagner S, Kaufels N, Wagner M.
Rofo. 2012 Feb;184(2):105-112. Epub 2011 Dec 16.

Combined in situ zymography, immunofluorescence, and staining of iron oxide particles in paraffin-embedded, zinc-fixed tissue sections.
Haeckel A, Schoenzart L, Appler F, Schnorr J, Taupitz M, Hamm B, Schellenberger E.
Mol Imaging. 2012 Sep-Oct;11(5):383-8.

Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracer.
Kratz H, Haeckel A, Michel R, Schönzart L, Hanisch U, Hamm B, Schellenberger E.
EJNMMI Res. 2012 Apr 27;2(1):17. doi: 10.1186/2191-219X-2-17.

Electrostatically Stabilized Magnetic Nanoparticles - An Optimized Protocol to Label Murine T Cells for in vivo MRI
Wuerfel E, Smyth M, Millward JM, Schellenberger E, Glumm J, Prozorovski T, Aktas O, Schulze-Topphoff U, Schnorr J, Wagner S, Taupitz M, Infante-Duarte C, Wuerfel J.
Front Neurol. 2011;2:72. Epub 2011 Dec 16

Combined In Situ Zymography, Immunofluorescence, And Staining Of Iron Oxide Particles In Paraffin-embedded, Zinc-fixed Tissue Sections.
Haeckel A, Schoenzart L, Appler F, Schnorr J, Taupitz M, Hamm B., Schellenberger E.
Mol Imaging. 2011;11(5):1-6.

Bioresponsive nanosensors in medical imaging.
Schellenberger E.
J R Soc Interface. 2010 Feb 6;7 Suppl 1:S83-91. Epub 2009 Oct 21.

Effects of water exchange on MRI-based determination of relative blood volume using an inversion-prepared gradient echo sequence and a blood pool contrast medium.
Carreira GC, Gemeinhardt O, Beyersdorff D, Schnorr J, Taupitz M, Lüdemann L.
Magn Reson Imaging. 2009 Apr;27(3):360-9. Epub 2008 Sep 2.

Protease-specific nanosensors for magnetic resonance imaging.
Schellenberger E, Rudloff F, Warmuth C, Taupitz M, Hamm B, Schnorr J. 
Bioconjug Chem. 2008 Dec;19(12):2440-5

Inhibition of restenosis in femoropopliteal arteries: paclitaxel-coated versus uncoated balloon: femoral paclitaxel randomized pilot trial.
Werk M, Langner S, Reinkensmeier B, Boettcher HF, Tepe G, Dietz U, Hosten N, Hamm B, Speck U, Ricke J.
Circulation. 2008 Sep 23;118(13):1358-65. Epub 2008 Sep 8.

Magnetic resonance imaging of liver metastases: experimental comparison of anionic and conventional superparamagnetic iron oxide particles with a hepatobiliary contrast medium during dynamic and uptake phases.
Kaufels N, Korn R, Wagner S, Schink T, Hamm B, Taupitz M, Schnorr J.
Invest Radiol. 2008 Jul;43(7):496-503.

Linking proteins with anionic nanoparticles via protamine: ultrasmall protein-coupled probes for magnetic resonance imaging of apoptosis.
Schellenberger E, Schnorr J, Reutelingsperger C, Ungethüm L, Meyer W, Taupitz M, Hamm B.
Small. 2008 Feb;4(2):225-30.

Neointima inhibition: comparison of effectiveness of non-stent-based local drug delivery and a drug-eluting stent in porcine coronary arteries.
Speck U, Scheller B, Abramjuk C, Breitwieser C, Dobberstein J, Boehm M, Hamm B. 
Radiology. 2006 Aug;240(2):411-8.

Focal Liver Lesions: SPIO-, Gadolinium-, and Ferucarbotran-enhanced Dynamic T1-weighted and Delayed T2-weighted MR Imaging in Rabbits.
Schnorr J, Wagner S, Abramjuk C, Drees R, Schink T, Schellenberger EA, Pilgrimm H, Hamm B, Taupitz M.
Radiology. 2006 Jul;240(1):90-100. Epub 2006 May 9.

Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats.
Abramjuk C., Jung K., Krell H.W., Juchem R., Peters R., Taymoorian K., Staack A., Stephan C., Schnorr J., Loening S.A. & Lein M.
Anti-Cancer Drug: 16(8) 855-61, Jahr: "2005"

Differentiation of prostate cancer from normal prostate tissue in an animal model: conventional MRI and dynamic contrast-enhanced MRI.
Gemeinhardt O., Lüdemann L., Prochnow D., Abramjuk C., Taupitz M., Hamm B. & Beyersdorff D.
Rofo-Fortschr Rontg: 177(7) 935-9, Jahr: "2005"

Implementation of a rapid inversion-prepared dual-contrast gradient echo sequence for quantitative dynamic contrast-enhanced magnetic resonance imaging of the human prostate.
Prochnow D., Beyersdorff D., Warmuth C., Taupitz M., Gemeinhardt O. & Lüdemann L.
Magn Reson Imaging: 23(10) 983-90, Jahr: "2005"

[Applications of optical imaging]
Schellenberger E.
Z Med Phys: 15(3) 187-91, Jahr: "2005"

Drug delivery by angiographic contrast media: inhibition of restenosis.
Speck U., Scheller B., Abramjuk C. & Bernhardt U.
Acad Radiol: 12 Suppl 1 S14-7, Jahr: "2005"

Surface-functionalized nanoparticle library yields probes for apoptotic cells.
Schellenberger E.A., Reynolds F., Weissleder R. & Josephson L.
Chembiochem: 5(3) 275-9, Jahr: "2004"

Optimal modification of annexin V with fluorescent dyes.
Schellenberger E.A., Weissleder R. & Josephson L.
Chembiochem: 5(3) 271-4, Jahr: "2004"

Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs.
Schnorr J., Wagner S., Abramjuk C., Wojner I., Schink T., Kroencke T.J., Schellenberger E., Hamm B., Pilgrimm H. & Taupitz M.
Invest Radiol: 39(9) 546-53, Jahr: "2004"

Inhibition of restenosis in stented porcine coronary arteries: uptake of Paclitaxel from angiographic contrast media.
Speck U., Scheller B., Abramjuk C., Grossmann S., Mahnkopf D. & Simon O.
Invest Radiol: 39(3) 182-6, Jahr: "2004"

Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging.
Taupitz M., Wagner S., Schnorr J., Kravec I., Pilgrimm H., Bergmann-Fritsch H. & Hamm B.
Invest Radiol: 39(7) 394-405, Jahr: "2004"

[MR angiography of the coronary arteries: comparison of the blood pool contrast medium Gadomer and Gd-DTPA in pigs]
Schnorr J., Wagner S., Ebert W., Heyer C., Laub G., Kivelitz D., Abramjuk C., Hamm B. & Taupitz M.
Rofo-Fortschr Rontg: 175(6) 822-9., Jahr: "2003"