AG Molekulare Bildgebung

Team leader
Prof. Dr. med. Eyk Schellenberger 
Professor of Radiology with focus on basic research 

Scientific staff 
Dr. rer. nat. Akvile Häckel 
Biologist 

PhD-students
Alejandro Betancourt 
PhD student of medicine 
Jing Xie 
PhD student of medicine 
Lena Ascher 
PhD student of biochemistry
Fei Ni
PhD student of medicine
Liu Lang
PhD student of medicine​​​​​​​

Previous Personnel 

• Dr. rer. nat. Constantin Scharlach 
• Dr. rer. nat. Franziska Appler 
• Dr. rer. medic. C. Warmuth, Physicist 
• Gesche Genter, CTA 
• Dr. rer. nat. Lena Figge 
• Randall Lindquist, MD, PhD 
• Dr. rer. nat. Sebastian Papazoglou 
• Dr. rer. nat. Julia Maier, Pharmacist 
• Dr. rer. nat. Shibsekhar Roy 
• Dr. rer. nat. Wolfdietrich Meyer 

2002 - 2019

49. Application of Europium-Doped Very Small Iron Oxide Nanoparticles to Visualize Neuroinflammation with MRI and Fluorescence Microscopy.
Millward JM, Ariza de Schellenberger A, Berndt D, Hanke-Vela L, Schellenberger E, Waiczies S, Taupitz M, Kobayashi Y, Wagner S, Infante-Duarte C.
Neuroscience. 2019 Apr 1;403:136-144. doi: 10.1016/j.neuroscience.2017.12.014. Epub 2017 Dec 19
PubMed

48. Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine: A Proof-of-Concept Study in Mice Combining ICP-MS and Micro- and Nano-SR-XRF.
Wang S, Hesse B, Roman M, Stier D, Castillo-Michel H, Cotte M, Suuronen JP, Lagrange A, Radbruch H, Paul F, Taupitz M, Schellenberger E, Sack I, Infante-Duarte C.
Invest Radiol. 2019 Oct;54(10):617-626. doi: 10.1097/RLI.0000000000000571.
PubMed

47. Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel. Reichhart N, Schöberl S, Keckeis S, Alfaar AS, Roubeix C, Cordes M, Crespo-Garcia S, Haeckel A, Kociok N, Föckler R, Fels G, Mataruga A, Rauh R, Milenkovic VM, Zühlke K, Klussmann E, Schellenberger E, Strauß O. Sci Rep. 2019 Feb 19;9(1):2257. doi: 10.1038/s41598-018-37287-y. 
PubMed 

46. Gadolinium in human brain sections and colocalization with other elements.
El-Khatib AH, Radbruch H, Trog S, Neumann B, Paul F, Koch A, Linscheid MW, Jakubowski N, Schellenberger E.
Neurol Neuroimmunol Neuroinflamm. 2018 Oct 19;6(1):e515. doi: 10.1212/NXI.000000000000515. eCollection 2019 Jan. No abstract available.
PubMed

45. Drug Distribution and Basic Pharmacology of Paclitaxel/Resveratrol-Coated Balloon Catheters.
Speck U, Häckel A, Schellenberger E, Kamann S, Löchel M, Clever YP, Peters D, Scheller B, Trog S, Bettink S.
Cardiovasc Intervent Radiol. 2018 Oct;41(10):1599-1610. doi: 10.1007/s00270-018-2018-9. Epub 2018 Jul 2.
PubMed

44. Macrophage uptake switches on OCT contrast of superparamagnetic nanoparticles for imaging of atherosclerotic plaques.
Ariza de Schellenberger A, Poller WC, Stangl V, Landmesser U, Schellenberger E.
International Journal of Nanomedicine. 2018;Volume 13:7905-13.
PubMed

43. Low-Molecular-Weight Iron Chelates May Be an Alternative to Gadolinium-based Contrast Agents for T1-weighted Contrast-enhanced MR Imaging.
Boehm-Sturm P, Haeckel A, Hauptmann R, Mueller S, Kuhl CK, Schellenberger EA.
Radiology. 2018 Feb;286(2):537-546. doi: 10.1148/radiol.2017170116. Epub 2017 Sep 7.
PubMed

42. Application of Europium-Doped Very Small Iron Oxide Nanoparticles to Visualize Neuroinflammation with MRI and Fluorescence Microscopy.
Millward JM, Ariza de Schellenberger A, Berndt D, Hanke-Vela L, Schellenberger E, Waiczies S, Taupitz M, Kobayashi Y, Wagner S, Infante-Duarte C.
Neuroscience. 2017 Dec 19. pii: S0306-4522(17)30886-2. doi: 10.1016/j.neuroscience.2017.12.014. [Epub ahead of print]
PubMed

41. Synthesis of europium-doped VSOP, customized enhancer solution and improved microscopy fluorescence methodology for unambiguous histological detection.
Ariza de Schellenberger A, Hauptmann R, Millward JM, Schellenberger E, Kobayashi Y, Taupitz M, Infante-Duarte C, Schnorr J, Wagner S
J Nanobiotechnology. 2017 Oct 10;15(1):71. doi: 10.1186/s12951-017-0301-6.
PubMed

40. XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic.
Haeckel A, Appler F, Ariza de Schellenberger A, Schellenberger E
PLoS One. 2016;11:e0157193.
PubMed

39. Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells.
Poller WC, Ramberger E, Boehm-Sturm P, Mueller S, Möller K, Löwa N, Wiekhorst F, Wagner S, Taupitz M, Schellenberger E, Baumann G, Stangl K, Stangl V, Ludwig A
Nano Research. 2016;9:3437-52.
PubMed

38. LA-ICP-MS Allows Quantitative Microscopy of Europium-Doped Iron Oxide Nanoparticles and is a Possible Alternative to Ambiguous Prussian Blue Iron Staining
Scharlach, C., Müller, L., Wagner, S., Kobayashi, Y., Kratz, H., Ebert, M., Jakubowski, N. & Schellenberger, E.
Journal of biomedical nanotechnology, 2016 12(5), pp. 1001-10
PubMed

37. Labeling of mesenchymal stem cells for MRI with single-cell sensitivity
Ariza de Schellenberger, A., Kratz, H., Farr, T., Loewa, N., Hauptmann, R., Wagner, S., Taupitz, M., Schnorr, J. & Schellenberger, E.
International journal of nanomedicine, 2016, p. 1517.
PubMed

36. Determination of blood circulation times of superparamagnetic iron oxide nanoparticles by T2* relaxometry using ultrashort echo time (UTE) MRI.
Scharlach C, Warmuth C, Schellenberger E.
Magn Reson Imaging. 2015 Nov;33(9):1173-7. doi: 10.1016/j.mri.2015.06.017. Epub 2015 Jun 26.
PubMed

35. Synthesis of acid-stabilized iron oxide nanoparticles and comparison for targeting atherosclerotic plaques: evaluation by MRI, quantitative MPS, and TEM alternative to ambiguous Prussian blue iron staining.
Scharlach C, Kratz H, Wiekhorst F, Warmuth C, Schnorr J, Genter G, Ebert M, Mueller S, Schellenberger E.
Nanomedicine. 2015 Jul;11(5):1085-95. doi: 10.1016/j.nano.2015.01.002. Epub 2015 Feb 4.
PubMed

34. Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis.
Figge L, Appler F, Chen HH, Sosnovik DE, Schnorr J, Seitz O, Taupitz M, Hamm B, Schellenberger E.
Contrast Media Mol Imaging. 2014 Jul-Aug;9(4):291-9. doi: 10.1002/cmmi.1575.
PubMed

33. XTEN-annexin A5: XTEN allows complete expression of long-circulating protein-based imaging probes as recombinant alternative to PEGylation.
Haeckel A, Appler F, Figge L, Kratz H, Lukas M, Michel R, Schnorr J, Zille M, Hamm B, Schellenberger E.
J Nucl Med. 2014 Mar;55(3):508-14. doi: 10.2967/jnumed.113.128108. Epub 2014 Feb 18.
PubMed

32. Monitoring stroke pregression: in vivo imaging of cortical perfusion, blood-brain barrier permeability and celluar damage in the rat photothrombosis model.
Schoknecht K, Prager O, Vazana U, Kamintsky L, Harhausen D, Zille M, Figge L, Chassidim Y, Schellenberger E, Kovács R, Heinemann U, Friedman A.
J Cereb Blood Flow Metab. 2014 Nov;34(11):1791-801. doi: 10.1038/jcbfm.2014.147. Epub 2014 Aug 27.
PubMed

31. Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke.
J Cereb Blood Flow Metab. 2013 May;33(5):e1-9. doi: 10.1038/jcbfm.2013.22. Epub 2013 Feb 27.
PubMed

30. Imaging of magnetic microfield disortions allows sensitive single-cell detection.
Lindquist RL, Papazoglou S, Scharlach C, Waiczies H, Schnorr J, Taupitz M, Hamm B, Schellenberger E.
Mol Imaging. 2013 Mar-Apr;12(2):83-9.
PubMed

29. Kratz H, Haeckel A, Michel R, Schönzart L, Hanisch U, Hamm B, Schellenberger E.
Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracer.
EJNMMI Res. 2012 Apr 27;2(1):17
PubMed

28. Schnorr J, Taupitz M, Schellenberger EA, Warmuth C, Fahlenkamp UL, Wagner S, Kaufels N, Wagner M.
Cardiac magnetic resonance angiography using blood-pool contrast agents: comparison of citrate-coated very small superparamagnetic iron oxide particles with gadofosveset trisodium in pigs.
Rofo. 2012 Feb;184(2):105-12
PubMed

27. Wuerfel E, Smyth M, Millward JM, Schellenberger E, Glumm J, Prozorovski T, Aktas O, Schulze-Topphoff U, Schnorr J, Wagner S, Taupitz M, Infante-Duarte C, Wuerfel J
Electrostatically Stabilized Magnetic Nanoparticles - An Optimized Protocol to Label Murine T Cells for in vivo MRI.
Front Neurol. 2011;2:72. Epub 2011 Dec 16
PubMed

26. Wagner M, Wagner S, Schnorr J, Schellenberger E, Kivelitz D, Krug L, Dewey M, Laule M, Hamm B, Taupitz M.
Coronary MR angiography using citrate-coated very small superparamagnetic iron oxide particles as blood-pool contrast agent: initial experience in humans.
J Magn Reson Imaging. 2011 Oct;34(4):816-23.
PubMed

25. Bahmani P., Schellenberger E., Klohs J., Steinbrink J., Cordell R., Zille M., Müller J., Harhausen D., Hofstra L., Reutelingsperger C., Dirnagl U., and Wunder A.
(2011) Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining.
J Cereb Blood Flow Metab
PubMed

24. Haeckel A, Schoenzart L, Appler F, Schnorr J, Taupitz M, Hamm B., Schellenberger E,
Combined In Situ Zymography, Immunofluorescence, And Staining Of Iron Oxide Particles In Paraffin-embedded, Zinc-fixed Tissue Sections.
Mol Imaging. 2011;11(5):1-6.
PubMed

23. Schellenberger E.
Bioresponsive nanosensors in medical imaging.
J R Soc Interface. 2010 Feb 6;7 Suppl 1:S83-91. Epub 2009 Oct 21.
PubMed

22. Schellenberger E, Rudloff F, Warmuth C, Taupitz M, Hamm B, Schnorr J.
Protease-specific nanosensors for magnetic resonance imaging.
Bioconjug Chem. 2008 Dec;19(12):2440-5
PubMed

21. Schellenberger, E., Schnorr, J., Reutelingsperger, C., Ungethum, L
et al. Linking Proteins with Anionic Nanoparticles via Protamine: Ultrasmall Protein-Coupled Probes for Magnetic Resonance Imaging of Apoptosis.
Small 4, 225-230 (2008).
PubMed

20. Schellenberger, E.
in Nanoparticles in Biomedical Imaging T1 - Magnetoptical Probes
199-207 (Springer 2007).

19. Schellenberger E, Wagner S, Schnorr J.
in Production of targeted MRI probes by biocompa-tible coupling of macromolecules with charged nanoparticles.
Patent application 07015538.7-1216, 2007.

18. Schellenberger, E.
in Textbook of in vivo Imaging in Vertebrates
(eds Tavitian, B., Leroy-Willig, A. & Ntziachristos, V.) 301 (John Wiley & Sons, Ltd, 2007).

17. Morawietz, H., Rohrbach, S., Rueckschloss, U., Schellenberger, E.
et al. Increased cardiac endothelial nitric oxide synthase expression in patients taking angiotensin-converting enzyme inhibitor therapy.
Eur J Clin Invest 36, 705-712 (2006).
PubMed

16. Schnorr J, Wagner S, Abramjuk C, Drees R, Schink T, Schellenberger EA, Pilgrimm H, Hamm B, Taupitz M.
et al. Focal Liver Lesions: SPIO-, Gadolinium-, and Ferucarbotran-enhanced Dynamic T1-weighted and Delayed T2-weighted MR Imaging in Rabbits.
Radiology (2006).
PubMed

15. Sosnovik, D. E., Schellenberger, E. A., Nahrendorf, M., Novikov, M. S.
et al. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle.
Magn Reson Med 54, 718-724 (2005).
PubMed

14. Wunder, A., Schellenberger, E., Mahmood, U., Bogdanov, A.J.
et al. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis.
Mol Imaging 4, 1-6 (2005).
PubMed

13. Schellenberger, E.
[Applications of optical imaging].
Z Med Phys 15, 187-191 (2005).
PubMed

12. Schellenberger, E. A., Sosnovik, D., Weissleder, R. & Josephson, L.
Magneto/optical annexin V, a multimodal protein.
Bioconjug Chem 15, 1062-1067 (2004).
PubMed

11. Schellenberger, E. A., Weissleder, R. & Josephson, L.
Optimal modification of annexin V with fluorescent dyes.
Chembiochem 5, 271-274 (2004).
PubMed

10. Schellenberger, E. A., Reynolds, F., Weissleder, R. & Josephson, L.
Surface-functionalized nanoparticle library yields probes for apoptotic cells.
Chembiochem 5, 275-279 (2004).
PubMed

9. Bogdanov, A, Schellenberger, E, Petrovsky, A and Josephson, L.
In vivo imaging of apoptosis. WO 03/105814.

8. Schnorr, J., Wagner, S., Abramjuk, C., Wojner, I.
et al. Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs.
Invest Radiol 39, 546-553 (2004).
PubMed

7. Ntziachristos, V., Schellenberger, E. A., Ripoll, J., Yessayan, D.
et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Proc Natl Acad Sci U S A 101, 12294-12299 (2004).
PubMed

6. Petrovsky, A., Schellenberger, E., Josephson, L., Weissleder, R. & Bogdanov, A. Jr.
Near-infrared fluorescent imaging of tumor apoptosis.
Cancer Res 63, 1936-1942 (2003).
PubMed

5. Schellenberger, E. A., Josephson, L. & Ntziachristos, V.
Optical Imaging of Apoptosis.
Medical Laser Application 18, 191-198 (2003).

4. Schellenberger, E. A., Bogdanov, A. J., Petrovsky, A., Ntziachristos, V.
et al. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy.
Neoplasia 5, 187-192 (2003).
PubMed

3. Schellenberger, E. A., Hogemann, D., Josephson, L. & Weissleder, R.
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Acad Radiol 9 Suppl 2, S310-S311 (2002).
PubMed

2. Wunderbaldinger, P., Bremer, C., Schellenberger, E., Cejna, M.
et al. Imaging features of iliopsoas bursitis.
Eur Radiol 12, 409-415 (2002).
PubMed

1. Schellenberger, E. A., Bogdanov, A., J., Hogemann, D., Tait, J.
et al. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Mol Imaging 1, 102-107 (2002).
PubMed